C L s t p a t h   2006
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Wednesday,  June 21st 2006    
15:00-18:00 Registration Law and Social Sciences Building, B-Floor Atrium 


Keynote Address

Bruce McClane (University of Pittsburgh School of Medicine,  USA)

Clostridium perfringens Enterotoxin: Foe and Friend?

19:30-24:00 Welcome Reception University Staff Club
Thursday, June 22nd 2006
07:00-08:30 Breakfast Hugh Stewart & Cripps Hall
08:30-10:30 Session I:     Epidemiology and Diagnosis (Chair: Jon Brazier)  
  08.30-09.00 Dale Gerding (VA Hospital, USA ) Clinical aspects of Clostridium difficile
  09.00-09.30 Maja Rupnik (Institute for Public Health, Maribor, Slovenia) Epidemiology of Clostridium difficile 
  09.30-09.50 Jim McLauchlin (HPA Centre for Infections, London, UK)  Wound botulism in injecting drug users in the UK
  09.50-10.10 Oliver Hasselmeyer (University of Mainz, Germany) Use  of the CdISt1 IStron for typing of Clostridium difficile outbreaks
  10.10-10.30 Denise Drudy (University College Dublin, Ireland) Fluoroquinolone resistance in toxin A negative toxin B positive Clostridium difficile associated with a novel mutation in GYRB
10:30-11:00 Coffee break Law and Social Sciences Building Atrium
11:00-13:00 Session II: Entertoxins & Membrane Active Toxins - Part I (Chair: Maja Rupnik)
  11.00-11.30 Ingo Just (Hannover Medical School, Germany) Clostridium difficile toxin A mode of action
  11.30-12.00 Jim Ballard (University of Oklahoma, USA) Decreased Akt-Signaling and Related Events During Early Stages of Cellular Intoxication by Clostridium sordellii TcsL
  12.00-12.30 Klaus Aktories (University of Freiburg, Germany) The crystal structure of Clostridium difficile toxin B
  12.30-13.00 Michel Popoff / Blandine Geny (Institute Pasteur, France) In vitro and in vivo effects of Clostridium sordellii lethal toxin on intercellular junctions
13:00-14:30 Lunch Hugh Stewart Hall
14.30-16.30 Session III: Entertoxins & Membrane Active Toxins - Part II (Chair: Julian Rood)
  14.30-15.00 Ajit Basak (Birkbeck College, UK) Structure of C. perfringens epsilon toxin
  15.00-15.30 Rick Titball (DSTL, UK) Vaccines against Clostridium perfringens alpha-toxin
  15.30-15.50 James Smedley (University of Pittsburgh, USA) Investigating post-binding steps in the mechanism of action of C. perfringens enterotoxin
  15.50-16.10 Mariano Fernandez-Miyakawa (University of California, Davis, USA) Clostridium perfringens epsilon toxin increases small intestine permeability
  16.10-16.30 Johannes Huelsenbeck (Hannover Medical School, Germany) Upregulation of rhob by clostridial cytotoxins
16:30-18:00 Posters I Law and Social Sciences Building Atrium
20:00-22.00 Dinner Hugh Stewart Hall
Friday, June 23rd 2006
07:00-08:30 Breakfast Hugh Stewart & Cripps Hall
08:30-10:30 Session IV: Neurotoxins (Chair: Ornella Rossetto)
08.30-09.00 Eric Johnson (University of Wisconsin, USA ) Clostridium botulinum neurotoxin subtypes and their biological significance
  09.00-09.30 Thomas Binz (University of Hannover, Germany) The sugar binding domain of clostridial neurotoxins
  09.30-09.50 Miia Lindstrom (University of Helsinki, Finland) Genomic comparison of group I (proteolytic) Clostridium botulinum Type B
  09.50-10.10 Andreas Rummel (Meizininische Hochschule, Hannover, Germany) Interaction with one ganglioside and one protein receptor mediates the neurotoxicity of Botulinum neurotoxins
  10.10-10.30 Frank Lebeda (USAMRIID, USA.) Botulinum neurotoxin: A toxicokinetic study
10:30-11:00 Coffee break Law and Social Sciences Building Atrium
11:00-13:00 Session V: Treatment & Exploitation (Chair: Glen Songer)
  11.00-11.30 Jan Theys (University of Maastricht, Holland ) Clostridial Spores and Cancer Therapy
  11.30-12.00 Neil Green (Vanderbilt University, USA) Inhibitors of Botulinum Neurotoxin 
  12.00-12.20 Yue Chen (University of Pittsburgh, USA) Sequence specific mutagenesis by Targetron: disrupt endogenous genes and introduce foreign gene into C. perfringens chromosome
  12.20-12.40 Ian. Cheong (Howard Hughes Medical Institute, USA) C. novyi can generate a potent therapeutic immune response against experimental tumours
  12.40-13.00 Kristin Nagaro (Hines V.A. Hospital, Illinois, USA.) Non-Toxic Clostridium difficile (CD) protects hamsters against historic and epidemic toxigenic "BI" strains
13:00-14:30 Lunch Hugh Stewart Hall
14:30-16:30 Session VI: Veterinary Disease (Chair: Marietta Flores-Díaz)
  14.30-15.00 Glenn Songer (University of Arizona, USA ) Clostridial enteritis in domestic animal species
15.00-15.30 Francisco Uzal (University of California, USA) A mouse model for C. perfringens type D infection
  15.30-15.50 Luis Arroyo (University of Guelph, Canda) Clostridium difficile: potential causes of duodenitis proximal jejunitis in horses
15.50-16.10 Filip Van Immerseel (Ghent University, Belgium) Clinical isolates of Clostridium perfringens in poultry are not superior alpha toxin producers in vitro
  16.10-16.30 Anthony Keyburn (Australian Animal Health Laboratory, Geelong, Australia) The alpha toxin of Clostridium perfringens is not an essential virulence factor in necrotic enteritis in chickens
16:30-18:00 Posters II Law and Social Sciences Building Atrium
20:00-22.00 Dinner Hugh Stewart Hall
Saturday, June 24th 2006
07:00-08:30 Breakfast Hugh Stewart & Cripps Hall
08:30-10:30 Session VII: Host-Pathogen Interactions (Chair: Paola Mastrantonio)
  08.30-09.00 Steve Melville (VPI, USA ) The interaction of C. perfringens toxins with macrophages
  09.00-09.30 Marietta Flores-Díaz (University of Costa Rica, Costa Rica) The cytotoxic effects of Clostridium perfringens α-toxin is mediated by endogenous mediators
  09.30-09.50 Clair Janoir

(Université Paris-Sud, France) The CWP84 surface associated protein of

Clostridium difficile is a cysteine protease with degrading activity against

extracellular matrix proteins

  09.50-10.10 Elaine Hamm (University of Oklahoma, USA.) Characterisation of the systemic effects of Clostridium difficile TcdB using developing Zebrafish embryos
10.10-10.30 Derek Fisher (University of Pittsburgh School of Medicine, U.S.A.) The Role of Toxins from Clostridium perfringens Type C in the Mouse Intravenous Injection Model
10:30-11:00 Coffee break Law and Social Sciences Building Atrium
11:00-13:00 Session VIII: Genetics and Physiology (Chair: Nigel Minton)
  11.00-11.30 Mahfuz Sarker (Oregon State University, USA ) C. perfringens sporulation
  11.30-12.00 Trudi Bannam (Monash University, Australia) The mechanism of conjugation in C. perfringens
  12.00-12.20 Jennifer O'Connor (Monash University, Australia) Construction and transcriptional analysis of Clostridium difficile response regulator mutants
  12.20-12.40 Hubert Bahl (University of Rostock, Germany) Analysis of proteins involved in the oxidative stress response of Clostridium acetobutylicum
  12.40-13.00 Kazauki Miyamoto (Wakayama Medical University, Japan) Sequencing and diversity analysis of the enterotoxin-encoding plasmids in Clostridium perfringens type a nonfoodborne human gastrointestinal disease isolates
13:00-14:30 Lunch Hugh Stewart Hall
14:30-16:30 Session IX: Genomics, proteomics and transcriptomics (Chair: Peter Mullany)
  14.30-15.00 Mike Peck (IFR Norwich, UK ) Exploitation of the Clostridium botulinum Genome Sequence
  15.00-15.30 Richard Stabler (LSTMH, London, UK) Comparative phylogenomics of C. difficile reveals clade specificity and microevolution of hypervirulent strains.
  15.30-15.50 Yoshihiko Sakaguchi (Okayama University, Japan) The Genome sequence of Clostridium botulinum Type C neurotoxin-converting phage and the molecular mechanisms of unstable lysogeny
  15.50-16.10 Katrin Schwarz (University of Rostock, Germany) The intra and extracellular proteome of Clostridium acetobutylicum under phosphate limitation
  16.10-16.30 Kaori Ohtani (Kanazawa University, Japan) Biological signaling to gene expression in Clostridium perfringens.
16:30-17:00 Coffee Law and Social Sciences Building Atrium
17:00-19:00 Session X: Regulation of Virulence Genes (Chair: Anne Collignon)
17.00-17.30 Bruno Dupuy (Institute Pasteur, France) Regulation of clostridial toxins by alternative sigma factors
17.30-18.00 Akinobu Okabe (University of Kagawa, Japan) DNA curvature and gene regulation in Clostridium perfringens
18.00-18.20 Susana Matamouros (Institute Pasteur, France) Toxin synthesis regulation in Clostridium difficile
18.20-18.40 Sean Dineen

(Tufts University School of Medicine, USA) Regulation of Clostridium difficile Toxin Synthesis


Farida Siddiqui

(Hines V.A. Hospital, Illinois, USA.) The tcdC gene of C. difficile variants including the epidemic BI strain contains stop codons and deletions

20.00-24:00 Medieval Banquet Nottingham  - Tales of Robin Hood
Sunday, June 25th 2006
07:00-08:30 Breakfast Hugh Stewart & Cripps Hall
  Special Open Public - Session for the Person in the Street  - Click HERE for details


Email:Clostpath Secretariat for further information [updated 8-May-06 ]






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