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FINAL
PROGRAMME |
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Download pdf
version -
HERE |
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Wednesday, June
21st 2006 |
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15:00-18:00
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Registration |
Law and Social Sciences Building, B-Floor Atrium |
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18.00-19:00
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Keynote Address
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Bruce McClane
(University
of Pittsburgh School of Medicine, USA)
Clostridium perfringens
Enterotoxin: Foe and Friend?
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19:30-24:00 |
Welcome Reception |
University Staff Club |
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Thursday, June
22nd 2006 |
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07:00-08:30 |
Breakfast
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Hugh Stewart & Cripps Hall |
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08:30-10:30 |
Session I:
Epidemiology and Diagnosis (Chair: Jon Brazier) |
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08.30-09.00
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Dale Gerding
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(VA Hospital,
USA ) Clinical
aspects of Clostridium difficile |
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09.00-09.30 |
Maja Rupnik |
(Institute
for Public Health,
Maribor, Slovenia)
Epidemiology of Clostridium difficile
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09.30-09.50 |
Jim McLauchlin |
(HPA Centre for
Infections, London, UK) Wound botulism in injecting
drug users in the UK |
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09.50-10.10 |
Oliver Hasselmeyer |
(University
of Mainz,
Germany)
Use of the
CdISt1 IStron for typing of
Clostridium difficile outbreaks |
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10.10-10.30 |
Denise Drudy |
(University College
Dublin, Ireland) Fluoroquinolone resistance in toxin A negative
toxin B positive
Clostridium
difficile
associated with a
novel
mutation in GYRB |
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10:30-11:00 |
Coffee break |
Law and Social Sciences Building Atrium |
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11:00-13:00 |
Session II:
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Entertoxins &
Membrane
Active Toxins
- Part I
(Chair:
Maja Rupnik) |
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11.00-11.30
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Ingo Just |
(Hannover
Medical School, Germany)
Clostridium
difficile toxin A
mode
of action |
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11.30-12.00 |
Jim
Ballard |
(University of
Oklahoma, USA)
Decreased Akt-Signaling and Related Events During Early Stages
of Cellular Intoxication by Clostridium sordellii TcsL |
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12.00-12.30 |
Klaus Aktories |
(University of
Freiburg, Germany) The crystal structure of Clostridium
difficile toxin B |
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12.30-13.00 |
Michel Popoff /
Blandine Geny |
(Institute
Pasteur, France) In
vitro and in vivo effects of Clostridium
sordellii
lethal
toxin
on intercellular
junctions |
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13:00-14:30 |
Lunch
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Hugh Stewart Hall |
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14.30-16.30 |
Session III:
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Entertoxins &
Membrane
Active Toxins
- Part II
(Chair: Julian Rood) |
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14.30-15.00
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Ajit
Basak |
(Birkbeck
College, UK)
Structure of C. perfringens
epsilon toxin |
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15.00-15.30 |
Rick
Titball |
(DSTL, UK)
Vaccines against Clostridium perfringens alpha-toxin |
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15.30-15.50 |
James Smedley |
(University of
Pittsburgh, USA) Investigating post-binding steps in the
mechanism of action of C. perfringens enterotoxin |
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15.50-16.10 |
Mariano Fernandez-Miyakawa |
(University of California, Davis, USA)
Clostridium
perfringens
epsilon toxin
increases small
intestine permeability |
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16.10-16.30 |
Johannes
Huelsenbeck |
(Hannover
Medical School, Germany)
Upregulation of
rhob
by
clostridial
cytotoxins |
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16:30-18:00 |
Posters I |
Law and Social Sciences Building Atrium |
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20:00-22.00 |
Dinner |
Hugh Stewart Hall |
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Friday,
June 23rd 2006 |
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07:00-08:30 |
Breakfast
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Hugh Stewart & Cripps Hall |
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08:30-10:30 |
Session IV:
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Neurotoxins
(Chair:
Ornella Rossetto)
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08.30-09.00
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Eric Johnson |
(University
of Wisconsin, USA )
Clostridium botulinum neurotoxin
subtypes and their biological significance |
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09.00-09.30 |
Thomas
Binz |
(University of
Hannover, Germany)
The
sugar binding domain of clostridial neurotoxins |
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09.30-09.50 |
Miia Lindstrom |
(University of
Helsinki, Finland) Genomic comparison of group I (proteolytic)
Clostridium
botulinum
Type B |
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09.50-10.10 |
Andreas Rummel |
(Meizininische
Hochschule, Hannover, Germany) Interaction with one ganglioside
and one protein receptor mediates the neurotoxicity of Botulinum
neurotoxins |
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10.10-10.30 |
Frank Lebeda |
(USAMRIID, USA.) Botulinum
neurotoxin: A toxicokinetic study |
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10:30-11:00 |
Coffee break |
Law and Social Sciences Building Atrium |
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11:00-13:00 |
Session V:
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Treatment & Exploitation
(Chair: Glen Songer) |
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11.00-11.30
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Jan Theys |
(University
of Maastricht, Holland )
Clostridial Spores and Cancer Therapy |
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11.30-12.00 |
Neil Green |
(Vanderbilt University,
USA)
Inhibitors of Botulinum Neurotoxin
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12.00-12.20 |
Yue
Chen |
(University
of Pittsburgh,
USA)
Sequence
specific
mutagenesis
by
Targetron: disrupt
endogenous
genes
and
introduce
foreign
gene
into
C. perfringens
chromosome |
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12.20-12.40 |
Ian. Cheong |
(Howard Hughes
Medical Institute, USA) C. novyi can generate a potent
therapeutic immune response against experimental tumours |
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12.40-13.00 |
Kristin Nagaro |
(Hines V.A.
Hospital, Illinois, USA.) Non-Toxic
Clostridium
difficile
(CD)
protects
hamsters
against
historic
and epidemic
toxigenic
"BI" strains |
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13:00-14:30 |
Lunch
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Hugh Stewart Hall |
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14:30-16:30 |
Session VI:
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Veterinary Disease
(Chair:
Marietta Flores-Díaz) |
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14.30-15.00
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Glenn Songer |
(University
of Arizona, USA )
Clostridial enteritis in domestic animal species |
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15.00-15.30 |
Francisco
Uzal |
(University
of California, USA)
A mouse model for C. perfringens type D infection |
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15.30-15.50 |
Luis Arroyo |
(University of
Guelph, Canda)
Clostridium
difficile:
potential causes of
duodenitis proximal jejunitis in horses |
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15.50-16.10 |
Filip Van Immerseel |
(Ghent University,
Belgium) Clinical isolates of
Clostridium
perfringens
in poultry are not superior
alpha toxin producers in vitro |
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16.10-16.30 |
Anthony
Keyburn |
(Australian Animal
Health Laboratory, Geelong, Australia) The alpha toxin of
Clostridium
perfringens is not
an
essential virulence
factor in necrotic enteritis
in chickens |
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16:30-18:00 |
Posters II |
Law and Social Sciences Building Atrium |
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20:00-22.00 |
Dinner |
Hugh Stewart Hall |
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Saturday,
June 24th 2006 |
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07:00-08:30 |
Breakfast
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Hugh Stewart & Cripps Hall |
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08:30-10:30
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Session VII:
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Host-Pathogen Interactions
(Chair: Paola Mastrantonio) |
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08.30-09.00
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Steve Melville |
(VPI,
USA )
The
interaction of C. perfringens
toxins with
macrophages |
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09.00-09.30 |
Marietta Flores-Díaz |
(University of
Costa Rica, Costa Rica) The
cytotoxic effects of Clostridium perfringens α-toxin is
mediated by endogenous mediators |
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09.30-09.50 |
Clair Janoir |
(Université
Paris-Sud, France)
The CWP84 surface associated protein of
Clostridium difficile is a cysteine
protease with degrading activity against
extracellular matrix proteins |
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09.50-10.10 |
Elaine Hamm |
(University of
Oklahoma, USA.) Characterisation of the systemic effects of
Clostridium difficile TcdB using
developing Zebrafish embryos |
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10.10-10.30 |
Derek Fisher |
(University
of Pittsburgh School of Medicine,
U.S.A.)
The Role of Toxins from
Clostridium
perfringens
Type C in the Mouse Intravenous Injection Model |
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10:30-11:00 |
Coffee break |
Law and Social Sciences Building Atrium |
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11:00-13:00 |
Session VIII:
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Genetics
and Physiology
(Chair: Nigel Minton) |
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11.00-11.30
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Mahfuz Sarker |
(Oregon
State University, USA )
C. perfringens
sporulation |
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11.30-12.00 |
Trudi Bannam |
(Monash
University,
Australia)
The mechanism of
conjugation in C. perfringens |
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12.00-12.20 |
Jennifer O'Connor |
(Monash University,
Australia) Construction and transcriptional analysis of
Clostridium difficile response
regulator mutants |
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12.20-12.40 |
Hubert Bahl |
(University of
Rostock, Germany) Analysis of proteins involved in the oxidative
stress response of Clostridium
acetobutylicum |
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12.40-13.00 |
Kazauki
Miyamoto |
(Wakayama
Medical University, Japan)
Sequencing and
diversity analysis of the enterotoxin-encoding plasmids in
Clostridium
perfringens type a nonfoodborne human gastrointestinal
disease isolates
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13:00-14:30 |
Lunch
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Hugh Stewart Hall |
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14:30-16:30 |
Session IX:
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Genomics, proteomics and transcriptomics
(Chair: Peter Mullany) |
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14.30-15.00
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Mike Peck |
(IFR
Norwich, UK )
Exploitation of the Clostridium
botulinum Genome Sequence |
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15.00-15.30 |
Richard Stabler |
(LSTMH,
London, UK) Comparative
phylogenomics of C.
difficile
reveals clade specificity and
microevolution of hypervirulent strains. |
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15.30-15.50 |
Yoshihiko Sakaguchi |
(Okayama
University, Japan) The Genome sequence of
Clostridium
botulinum
Type C neurotoxin-converting phage
and the molecular mechanisms of unstable lysogeny |
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15.50-16.10 |
Katrin Schwarz |
(University of
Rostock, Germany) The intra and extracellular proteome of
Clostridium acetobutylicum under
phosphate limitation |
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16.10-16.30 |
Kaori
Ohtani |
(Kanazawa
University, Japan) Biological signaling to
gene expression in Clostridium
perfringens. |
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16:30-17:00 |
Coffee |
Law and Social Sciences Building Atrium |
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17:00-19:00 |
Session X:
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Regulation of Virulence Genes
(Chair: Anne Collignon) |
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17.00-17.30
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Bruno Dupuy |
(Institute
Pasteur, France)
Regulation of clostridial toxins by alternative sigma factors |
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17.30-18.00 |
Akinobu Okabe |
(University of
Kagawa, Japan)
DNA curvature
and
gene regulation in Clostridium perfringens |
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18.00-18.20 |
Susana Matamouros |
(Institute
Pasteur, France)
Toxin synthesis
regulation in Clostridium difficile |
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18.20-18.40 |
Sean Dineen |
(Tufts University
School of Medicine, USA) Regulation of
Clostridium difficile Toxin
Synthesis |
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18.40-19.00 |
Farida Siddiqui |
(Hines V.A.
Hospital, Illinois, USA.) The tcdC gene of
C. difficile variants including the
epidemic BI strain contains stop codons and deletions |
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20.00-24:00 |
Medieval Banquet |
Nottingham
-
Tales of Robin Hood |
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Sunday,
June 25th 2006 |
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07:00-08:30 |
Breakfast
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Hugh Stewart & Cripps Hall |
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DEPART |
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Special Open Public - Session for the
Person in the Street - Click
HERE for details |
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