PROGRAMME - DOWNLOAD

MONDAY 19th OCTOBER 2009

15:30 - 18:00 Registration
16:30 - 17:00 Welcome Address
17:00 - 18:00 Keynote Lecture - The Impact of Genomics on Understanding Clostridial Pathogens - G Gottschalk - Göttingen Genomics Laboratory, Germany
18:00 - 19:30 Welcome Cocktail

TUESDAY 20th OCTOBER 2009

Session I : Molecular Epidemiology & Laboratory Diagnosis
CHAIR PERSON – Paola Mastrantonio
9:00 - 9:30 - Application of Molecular Methods to Diagnose CDI and to Study its Epidemiology - E. J. Kuijper - Leiden University Medical Center, The Netherlands.
9:30 - 9:50 - Novel Mass Spectral Approaches Based upon Surface-Associated and Stable Intra-Cellular Proteins for the High Throughput Identification of C. difficile. - L. Rajakaruna - HPA, London. UK
9:50 - 10:10 - Antibody-Mediated Enhanced Cytotoxicity of Clostridium difficile Toxin: Application in Diagnosis –  H. Feng - Tufts Cummings School of Veterinary Medicine, North Grafton, USA
10:10 - 10:30 - The Enterotoxin Gene (CPE) is Plasmid-Borne in Clostridium perfringens Type A Isolates Related to Sudden Infant Death Syndrome - A. Heikinheimo - University of Helsinki, Finland
10:30-11:00 Coffee break

Session II: Clostridial Toxins – Part 1
CHAIR PERSON – Maja Rupnik
11:00 - 11:30 - The Role of NetB toxin in Necrotic Enteritis - R. J Moore - Australian Animal Health Laboratory, Geelong, Australia.
11:30 - 11:50 - Studies of C. perfringens Enterotoxin: Claudin Interactions: Therapeutic Implications? - S.L.Robertson - University of Pittsburgh, USA.
11:50 - 12:10 - What Does the 3D-Structure of Clostridium perfringens Enterotoxin Reveal? - A. K. Basak - Birkbeck College, London, UK.
12:10 - 12:30 - TcsL is an Essential Virulence Factor in Clostridium sordellii - G.P. Carter - Monash University, Clayton, Australia.
12:30-14:00 Lunch

Session III : Clostridial Toxins – Part 2
CHAIR PERSON – Rick Titball
14:00 – 14:30  Clostridium difficile Toxins A and B: Progress in the Understanding of their Mode of Action - I. Just - Hannover Medical School, Germany.
14:30 - 14:50 - Toxin B is Essential for Virulence of Clostridium difficile - D. Lyras - Monash University, Clayton, Australia
14:50 - 15:10 - Deciphering the Role of TcdE in the Toxin Secretion of Clostridium difficile - B. Dupuy -  Institut Pasteur, Paris, France
15:10 - 15:30 - TcdE: The Silent Member in the Paloc of Clostridium difficile? – A. Olling, Hannover Medical School, Germany
15:30 – 16:00   Coffee break
16:00-18:00 Poster session I-III

WEDNESDAY 21st OCTOBER 2009

Session IV: Genomics, Metabolomics & Transcriptomics – Part 1
CHAIR PERSON – Wolfgang Liebl
9:00 - 9:30 - Insights Gained From the Study of Clostridium botulinum Genomes - T. J. Smith - USAMRIID, Fort Detrick, USA
9:30 - 9:50 - An Online Resource for Clostridium Genetic Tools - J.T. Heap - University of Nottingham , UK
9:50 - 10:10 - Cold Tolerance of Clostridium botulinum - M. Lindström - University of Helsinki, Finland
10:10 - 10:30 - Global Gene Regulation in Response to Cysteine Availability in Clostridium perfringens - I. Martin-Verstraete - Institut Pasteur, Paris, France.
10:30-11:00 Coffee break

Session V: Genomics, Metabolomics & Transcriptomics – Part 2
CHAIR PERSON – Nigel Minton
11:00 -11:30 -  Comparative Genome and Phenotypic Analysis of Clostridium difficile O27 Strains Provides Insight into the Evolution of  a Hypervirulent Bacterium – R.A. Stabler - London School of Hygiene & Tropical Medicine, London, UK
11:30 - 11:50 - Comparative Proteomic Analysis of Clostridium difficile - C. Chilton - HPA Centre for Infections, London, UK
11:50 - 12:10 - Transcriptional Profiling of Clostridium difficile and Caco-2 Cells During Infection - T. Janvilisri - Cornell University, Ithaca, USA
12:10 - 12:30 - Understanding the Pathogenesis of Clostridium difficile  by an in vivo Transcriptomic Approach - C. Janoir - Faculté de Pharmacie, Chatenay-Malabry, France
12:30-14:00 Lunch

Session VI: Regulation of Virulence Genes
CHAIR PERSON – Julian Rood
14:00-14:30 - Complex Regulatory Networks for Virulence in C. perfringens - T. Shimizu - Kanazawa University, Japan
14:30 - 14:50 - Regulation of NetB Production in Clostridium perfringens - J.K. Cheung - Monash University, Clayton, Australia.
14:50 - 15:10 - Impact of Carbon Catabolite Repression in the C. difficile Physiopathology - A. Antunes - Institut Pasteur, Paris, France.
15:10 - 15:30 - Elucidating the Mechanisms of Sporulation in Clostridium difficile - A. Faulds-Pain - University of Nottingham, UK, and HPA, UK
15:30-16:00 Coffee break
16:00- Networking Discussions

THURSDAY 22nd OCTOBER 2009

Session VII: Host-Pathogen Interactions
CHAIR PERSON – Glenn Songer
9:00-9:30 - Understanding the Role of Antibiotics in Inducing Clostridium difficile Iinfection - M. Wilcox - University of Leeds, UK.
9:30 - 9:50 - Passage of Botulinum Neurotoxin A through the Intestinal Barrier - M. R. Popoff - Institut Pasteur, Paris, France
9:50 - 10:10 - Biogenesis of the C. difficile S-Layer - R. P. Fagan - Imperial College London,
London, UK
10:10 - 10:30 - Contact with Enterocytes Causes Vir S/Vir R-Mediated Upregulation of Beta Toxin Production by C. perfringens Type C Isolates - J. E. Vidal - University of Pittsburgh, USA
10:30-11:00 Coffee break

Session VIII: Veterinary Diseases and Animal Models
CHAIR PERSON – Miia Lindström
11:00 - 11:30 – Main Clostridial Diseases in Animals - Viveca Båverud - National Veterinary Institute, Uppsala, Sweden
11:30 - 11:50 - Mouse Models for Studying Clostridium perfringens Type C Infections - F.A. Uzal - University of California, Davis, USA
11:50 - 12:10 - Epidemiology of Enterotoxaemia in Flemish Veal Calves - B. Pardon - Ghent University, Belgium
12:10 - 12:30 - Prevalence of Clostridium difficile in Piglets With and Without Diarrhoea in Australia - T.V. Riley - The University of Western Australia, Nedlands, Australia
12:30-14:00 Lunch

Session IX: Treatment & Exploitation
CHAIR PERSON – Bruce McClane
14:00-14:30 - Clostridia Associated Infections: New Weapons From Emerging Vaccines? –
I. Castagliuolo - University of  Padova, Italy
14:30 - 14:50 - A Live Recombinant Oral Vaccine Expressing Clostridium perfringens Antigens Confers Protection of Broiler Chickens Against Necrotic Enteritis - J. F. Prescott - University of Guelph, Canada,
14:50 - 15:20 - Clostridial Neurotoxins as a Platform for Novel Therapeutics - K. Foster - Syntaxin Limited, Abingdon, UK.
15:20 -15:40  Vaccination with Parenteral Toxoid B Protects Hamsters Against Lethal Challenge with Toxin A-Negative/B-Positive Clostridium difficile but does not Prevent Colonization - S. Johnson - Hines VA Hospital, Chicago, USA
15.40- 16:00  Antibody-Based Therapeutics for Clostridium difficile Infection - C. Shone - HPA, Porton Down, Salisbury, UK
16.00- 16:30 Coffee break
16:30-18:00 Poster session IV-IX
20:00-23:00 Farewell Dinner

FRIDAY 23rd OCTOBER 2009

Special Public Session
9:30-10:15   Clostridium Infections: Afflictions For All Seasons - Sherwood Gorbach - Tufts University School of Medicine, Boston, USA
10:15-10:30    Training the next generation of European Clostridium Researchers  -  Nigel Minton – Nottingham University, UK
10:30-11:00 Coffee Break
11:00-11:20 Clostridium botulinum in Italy - Paolo Aureli – Istituto Superiore di Sanità, Italy
11:20-11:40  Clostridium difficile in Italy - Paola Mastrantonio –  Istituto Superiore di Sanità,  Italy
11:40-12:00  Questions & Answers